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Mr. Guo Gang
Associate Chief Physician£¬Medical Postgraduate£¬Director of No.2 Department of Rheumatism ...[more] |
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Add£ºNo.385 XinShiBei Road, Shijiazhuang, Hebei, China.
Code£º050091
Tel£º0311-83836460
Free Phone£º400-612-2156
Fax£º0311-83832249
E-mail£ºyuanban@yiling.org
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Getting There: Take the city bus 22
Yiling Hospital Road Station or take 48,58,368Under the new Stone Road. |
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| Autologous stem cell transplantation of skin - to overcome limitations £¨contraction phase£© |
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In recent years, stem cell research has become a hot area of biological research in medicine, autologous stem cell transplantation in the treatment of myocardial infarction, diabetes and other nonvolatile memories. Stem cells are a class of self-renewal and differentiation potential of cells, including embryonic stem cells and adult stem cells. Stem cell development by affecting multiple internal mechanisms and micro-environmental factors. At present, human embryonic stem cells have been successfully cultured in vitro. The latest study found that adult stem cells can differentiate into other types of transverse cells and tissues, provides the basis for a wide range of applications stem cells. Many adult animal tissues and organs, such as the skin and the hematopoietic system, the ability to repair and regeneration. Adult stem cells plays a key role. Under certain conditions, to generate new stem cells or stem cells or differentiated according to a certain procedure, the formation of new functional cells, tissues and organs, thereby maintaining the dynamic balance of the growth and decline. Once the physiological needs, these stem cells can be split according to developmental pathways generated by the differentiated cells. Adult stem cells are often located in a particular microenvironment. Microenvironment mesenchymal cells to produce a series of growth factors or ligands, stem cell interactions with the control stem cell renewal and differentiation. Based on the above theory, our department researchers demonstrated through scientific analysis, autologous stem cell transplantation in the treatment of this advanced technology into the field of localized scleroderma, and achieved satisfactory clinical efficacy, according to medical information retrieval, using this method of treatment localized scleroderma contraction period, the first time in the country. Skin stem cells and injection treatments used in our department, the Department of Pharmaceutical Group I owned biotechnology company returned to Dr. international leading technology research and development.
Localized scleroderma is a limitation of skin swelling, hardening occurs gradually shrinking (some localized scleroderma always manifested as skin atrophy) of the skin disease, occur in the scalp, forehead (or unilateral facial), waist and abdomen limbs, slow progression of skin sclerosis, atrophy and pigmentation or depigmentation of clinical manifestations, skin lesions may have hair loss, decreased sweating, peripheral telangiectasia, etc., depending on the form of points patchy, ribbon, drip like, generalized, etc., which are more common patchy and ribbon. And a number of pathological changes in skin atrophy atrophy of localized scleroderma is thinning of the epidermis, dermis collagen fiber swelling, eosinophilic degeneration and destruction of elastic fibers break, the basal layer of pigment reduction, perivascular lymphocytes and histiocytes for Lord inflammatory infiltration, may have blood vessel wall thickening, lumen narrowing, sweat glands, sebaceous glands and hair follicles to shrink or decrease. Such diseases as clinical rare disease, its treatment has been a troubled patients and medical workers of the problem, Western medicine treatment of oral vitamin E, phenytoin, etc. efficacy are not plausible; Chinese medicine treatment is generally more to the spleen qi, warm the meridians, Huoxue Ruanjian for the rule is, but most patients longer course, the effect is not prominent.
For these reasons, atrophy of localized scleroderma and related skin atrophy caused great pain to patients, especially younger patients, some skin lesions on the face, the mental pressure is even greater. These diseases specialist over the years I conducted in-depth theoretical and clinical research, proposed a "skin ecological theory" - from multi-level, multi-angle analysis of the etiology and pathogenesis of localized scleroderma skin atrophy other limitations, continuing to explore modernization of Chinese medicine treatment modalities, with advanced equipment and cutting-edge technology combined with modern medicine, the formation of multi-link integrated treatment philosophy and the corresponding series of treatments, therapies complementary elements, specimens with mercy, multi-link, multi-target intervention, so that the efficacy of the treatment of localized scleroderma and other limitations of atrophic skin breakthrough improved. Over the years, our department by means of the Medical Group first-class traditional Chinese medicine research and preparation equipment, developed a variety of traditional Chinese medicine oral formulations, and has good absorption properties transdermal topical creams and herbal medicine import ultrasound coupling agents, such as iontophoresis solution, auxiliary to local drug injection, modern medicine Steam / water bath, etc., there is stasis and blood, yin heat, smooth network through the camp, since wilt wing skin effect, many patients can better therapeutic effect. But the treatment cycle is longer, can not meet the requirements to achieve clinical cure most patients in the short term. To this end our center researchers constantly strive to explore, to seek effective solutions to further improve the efficacy and shorten the course of treatment, autologous stem cell transplantation is one of the successful new therapeutic approach undertaken by our department.
Autologous stem cell transplantation in the treatment localized scleroderma, through the patient's skin cells after autologous isolated, amplified, and then injected into the lesion, these living cells have the ability to increase planting of differentiation, can shrink the skin and subcutaneous tissue repair, regeneration, and restore normal physiological state of the skin, effectively improve the localized scleroderma skin atrophy, dark color and other symptoms, especially for atrophic skin lesions such as Jianshang scleroderma, hemifacial atrophy, efficacy has been significantly improved, for a long time to bring the gospel of the disease caught in the majority of patients.
The study was carried out in our department with a strong technical support. Yiling Pharmaceutical Group Biological Engineering Company by Dr. returning from USA auspices of tissue engineering technology, strong technical force, hardware device class, to keep pace with international standards, has been developed for tissue engineering of autologous corneal epithelial stem cell therapy, tissue engineering of autologous skin composite skin stem cell therapy, tissue engineering of autologous skin fibroblast precursor cells injected wrinkle remove scar treatment technology, has made a breakthrough in the clinical research of skin stem cells. Hospital offers stem cell research, the neural stem cell transplantation, the clinical application of muscle stem cell transplantation has accumulated a wealth of experience for our department smoothly skin stem cells provide the preconditions transplant.
Skin stem cell transplantation in the treatment localized scleroderma, with the effect lasting effect is stable, the advantages of less invasive, and because autologous cell transplantation, so no rejection, has a good safety and tolerability, with the clinical applications carried out, will become a tool to overcome the limitations of scleroderma.
Autologous bone marrow stem cell transplantation
...... The latest weapon in the treatment of localized scleroderma
Stem cells are a class of self-renewal and differentiation potential of cells, including embryonic stem cells and adult stem cells. Adult stem cells can be differentiated into other types of transverse cells and tissues, a wide range of applications for the stem cells provides the basis. In recent years, stem cell research has become a hot field of bio-medical research, relevant technology matures, scleroderma treatment center researchers rely Yiling Pharmaceutical Group personnel and research strengths, successfully launched the "autologous bone marrow stem cell transplantation for treatment of localized scleroderma "the large number of clinical observations, and achieved a significant effect, according to medical information retrieval, using this method of treatment of localized scleroderma, first of its kind in the country, pioneered the technology for our department.
Bone marrow stem cell transplantation for treatment of localized scleroderma is a certain amount of bone marrow extracted from the patient, after in vitro isolation, made of autologous bone marrow stem cell injection, injected into the lesion site of the patient. The technique of autologous bone marrow stem cells, there is no rejection, and small surgical trauma, efficient and safe.
Bone marrow stem cells, including hematopoietic stem cells, mesenchymal stem cells and other components, after transplantation of bone marrow stem cells can differentiate in the transplant site for the tissue cells the body needs, and play repair and stimulate the growth of enzyme which produces and special peptides and other substances accelerated own tissue regeneration, it also induce immune tolerance, prompting local capillary proliferation, improve local metabolism and so on, so the method can inhibit the development of scleroderma, improve atrophy symptoms and improve nutritional and metabolic tissue lesions, help lesions of the skin and subcutaneous tissue repair, restore normal function of the skin has a positive effect. With the clinical application of this technology, our department localized scleroderma treatment efficacy was given a further improved.
2006 we will simultaneously carry out "autologous peripheral blood stem cell transplantation in the treatment localized scleroderma" therapeutic project that non-invasive, adapt to a wide range of higher technology content.
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