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Mr. Guo Gang
Associate Chief Physician£¬Medical Postgraduate£¬Director of No.2 Department of Rheumatism ...[more] |
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Clinical manifestati
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Clinical manifestati |
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| What is scleroderma renal crisis |
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| 10% of patients with scleroderma renal crisis may occur, in which 80% of the incidence of renal crisis appeared in the first four years. Generally occurs in winter. Patients with renal crisis may have a typical burst of malignant hypertension, headache, decreased vision, convulsions, seizures, confusion and even coma and other neurological changes, as well as congestive heart failure and rapidly progressive renal failure . Patients often diastolic blood pressure increased mainly hypertensive encephalopathy may occur. Associated with optic disc edema, retinal hemorrhage and exudation, plasma renin activity increased. Patients may also appear microangiopathic hemolytic anemia and thrombocytopenia, this situation is more common in patients with normal blood pressure, kidney crisis. Renal crisis occurs within a few weeks are often rapidly evolving as oliguric renal failure. According to reports an incidence of 10% to 40%, most of the patients to death from malignant hypertension occurs only less than three months. The localized scleroderma with anti-centromere antibody-positive does not happen much kidney crisis. |
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