Raynaud's phenomenon is often due to an early manifestation of systemic sclerosis, and may appear alone for many years, so there should be Raynaud's phenomenon of systemic lupus erythematosus, mixed connective tissue disease, Sjogren's syndrome, dermatomyositis, polymyositis, cold hypergammaglobulinemia, arteritis, identify disease frostbite, drug-induced scleroderma symptoms.

     Hardening of the skin manifestations, the need and morphea, strip scleroderma, identification eosinophilic fasciitis, neonatal scleredema, crusty mucus edema disease, porphyria, amyloidosis. There is damage to internal organs and nervous stomach weakness is required, identification of idiopathic pulmonary fibrosis, hereditary hemorrhagic telangiectasia, myocarditis.