Localized scleroderma change can be diagnosed based on typical skin.
     System sclerosis: American College of Rheumatology (ARA) 1998 year standard:
     A main criteria: the metacarpophalangeal joints proximal crusty change, can affect the entire body, face, body and torso.
     B minor criteria:

     ① finger scleroderma: these skin changes limited to the fingers;
     ② fingertips have depressed scars and finger pad disappear;
     ③ basal lung fibrosis.
     Where a major or two minor criteria standards can be diagnosed, other help diagnose performance: Raynaud's phenomenon, multiple arthritis or joint pain, esophageal motility abnormalities, skin collagen fiber swelling and fibrosis pathology, immunology check ANA , anti-Scl-70 antibodies, and centromere antibodies (ACA) positive.
     CREST syndrome, of which five specific symptoms three or more 3 plus centromere antibodies can be diagnosed.