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Mr. Guo Gang
Associate Chief Physician£¬Medical Postgraduate£¬Director of No.2 Department of Rheumatism ...[more] |
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Clinical manifestati
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Clinical manifestati |
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| Scleroderma patient¡®s skin and muscle biopsy sense? |
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Only patients with scleroderma skin damage while the other system damage is not obvious, sometimes the diagnosis is not clear, if a skin biopsy found within the reticular dermis dense collagen fibers increased, skin thinning, atrophy of skin appendages, and small arteries hyaline degeneration and fiber of, indicating activity of the skin becomes hard to change, the disease has diagnostic value.
Scleroderma patients, muscle biopsy, the patient's muscles to identify the disease symptoms are muscle damage or merge with a diagnosis of polymyositis. Scleroderma is a fibrous hyperproliferative disease affecting mainly muscle muscle fibers between the interstitial fiber hyperplasia, atrophy of muscle fibers can cause interstitial lymphocytic infiltration can; while polymyositis mainly autoimmune muscle inflammation, manifested as muscle fiber thickness ranging from part or all of the muscle fiber necrosis of muscle fibers have significant inflammatory cell infiltration, with the progress of the disease may have interstitial fibrosis. Therefore, the performance of the muscles involved in the early stage of the disease patients, muscle biopsy in the diagnosis of some help, but if it is late in the disease, muscle atrophy significantly, it is difficult to fully identify the pathology. |
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