| Scleroderma is a systemic connective tissue disease, the main features of the skin, synovium, skeletal muscle, blood vessels and esophagus fibrosis or sclerosis. Some of the internal organs, such as heart, kidney and arteries may also have similar sizes of lesions, but more common lung disease. The main manifestations of pulmonary fibrosis. Early may have no symptoms, but can be found in the gas diffusion spirometry dysfunction, then the patient may cough and difficulty in breathing after exercise. Pulmonary fibrosis, pulmonary vascular intimal fibrosis leading to stenosis or blockage, coupled with patients with severe Raynaud's phenomenon, not only in the extremities, can also cause small pulmonary vasoconstriction, resulting in pulmonary artery pressure increased, until right ventricular dysfunction caused by lead cor. Patients may have shortness of breath, palpitation, fatigue, purple lips (cyanosis), finger-like avatar small wooden club head, nail surface becomes arch up ("clubbing"), can have severe abdominal pain, do not eat incense, oliguria. When right heart failure, patients neck vessels plump, right upper quadrant palpable "lump" is the enlargement of the liver, pressing pain. Swollen legs, press down a depression. Pleurisy small number of patients may have chest pain, gasping when the pain worsened, but pleural effusion rare. The disease is often obvious lung epithelial hyperplasia bronchioles, making scleroderma patients with lung cancer incidence was higher than normal. |
