Clinically, systemic sclerosis can be divided into the following four types:
Diffuse scleroderma is more common, the performance of the symmetry of the limbs, facial skin becomes tight, hard, thickened, may involve the proximal extremities and neck, torso, accompanied by the gastrointestinal tract, kidneys, lungs, heart and other organs damage. This type is characterized by rapid onset, rapid progression of skin damage, damage to internal organs appeared earlier, the prognosis is poor; laboratory examination showed anti-Scl-70 antibodies, anti-centromere antibody can also be positive.
Acral sclerosis skin changes limited to this type of distal finger, forearm, leg and distal face, the skin of the above parts of the symmetry becomes tight, hard, thick, may be associated with Raynaud's phenomenon, and in disease pulmonary hypertension can occur later and cut that kind of change, some patients showed to skin and subcutaneous tissue calcification and telangiectasia for the outstanding performance of the CREST syndrome relatively good prognosis of this type, 10-year survival rate is greater than 70%; Laboratory examination showed anti-centromere antibody positive
Overlap syndrome diffuse or localized systemic sclerosis associated with one or more other connective tissue disease, it is called overlap syndrome.
No skin sclerosis in patients with systemic sclerosis only see this type of visceral lesions without hardening of the skin manifestations, can be expressed as follows: ¢Ù Esophageal Motility Disorders, duodenum expansion, the formation of colon bag ¢Ú Raynaud's phenomenon, nail fold telangiectasia, esophagus activities ¢Û disorders and oliguric renal failure among pulmonary hypertension associated with the above symptoms or lung disease. This type of patient is rare, less than 1%. |
