| Scleroderma have extensive vascular disease, including the arteries, small arteries, arterioles and capillaries, occasionally involving the aorta, skin, gastrointestinal tract, lung, heart, kidney and fingers and toes end arteries are involved, so some people think scleroderma is a result of a vascular endothelial lesions, namely primary vascular damage is significant intimal hyperplasia, concentric arrangement of cells were subsequently in endothelial cells, said fiber mucinous change. Vascular manifestations of scleroderma include early stages of edema, Raynaud's phenomenon, telangiectasia, capillary abnormalities and a wide range of multi-system disease. Fleischmajer examination revealed by electron microscopy, etc., changes in the first capillary scleroderma patients large cracks occur between the endothelial cells, these cracks can plasma extravasation into the extracellular matrix, resulting in fibrosis characteristic of prior cause early edema . After the occurrence of cracks, cell swelling, and then destroy the cells is released into the lumen, the results caused by capillary congestion. This iterative endothelial damage caused by replication of the substrate, each layer corresponds to the residue of a substrate of endothelial cell regeneration. |
