The cause of scleroderma is not yet fully understood. May be associated with a plurality of causal factors, including environmental factors and genetic basis.
It has been reported, the disease onset familial aggregation in systemic scleroderma patient's relatives, while suffering from the disease appear or another connective tissue disease, such as systemic lupus erythematosus.
Some patients found to have chromosomal abnormalities, HLA-¢ò (human leukocyte antigen -¢ò) genes with systemic scleroderma immune genetic, and therefore believe that the genetic basis of causative factors. |
