Scleroderma patients often insidious onset, many scleroderma patients before hardening of skin and internal organs, often the first to have encountered cold or stress, (toe) end of the pale, then purple, and finally turned purple, Raynaud's phenomenon appears. White and minority patients fingers began pale purple or sustained. Finger vascular spasm, resulting in poor blood supply, may be accompanied by numbness in hands, swelling, finger subcutaneous tissue atrophy, pulp thinning or depression, and even cause ulcers. 90% of scleroderma patients with Raynaud's phenomenon as the first symptom. Although Raynaud's phenomenon is also seen in other rheumatic diseases, but the most common in scleroderma.

     Scleroderma (ssc) is a clinically with localized or diffuse skin thickening or fibrosis is characterized by thickening of the skin according to the extent and location of the lesion violation of the disease can be divided into two categories, limitations sclerosis and systemic sclerosis. In addition, CREST syndrome, systemic sclerosis, a class of subtypes.
   
     Scleroderma patients with varying degrees of skin lesions, localized scleroderma generally mild, some patients only fingers and facial skin tight, hard, often after a very long time to appear visceral damage.

     Systemic scleroderma involving not only the patient's skin to harden the face, neck and limbs, but also involving the chest and abdomen and back. Typical skin lesions usually after three periods: the first period for the swelling, skin lesions - like the first in the fingers and face appeared, was swelling edema, pressure up no depression. Some patients may have skin erythema, pruritus, patients often feel like the hand swelling like a sausage, activities are not flexible; second period of hardening of the skin thickens, stiff fingers like being wrapped in leather, not like a normal human skin - samples can easily be raised, clenched fist with both hands can not. Skin lesions may gradually to the arm, neck, upper chest, abdomen and back spread, usually two legs rarely involved; atrophy of the third period, the skin becomes smooth but seemed very thin, tightly attached to the bone surface subcutaneous on. Flexion contracture can not be straightened, but also skin ulcers, painful and difficult to heal. Hardened skin thinning, striae disappear, even the hair also fell off. Face making facial skin hardens striae disappear, when emotions all gone expression, mouth can not open, can form a face mask. Characterized nose like a hawk nose, thin lips and radial contraction accompanied by difficulty in opening mouth. Late other body parts of the skin can gradually softened. Diffuse scleroderma patient's skin hardens places often have pigmentation, skin darkening, some parts of the formation of white color dropout, so sprinkled on the skin like "salt and pepper" like. Skin also has a lot of red thread above, is the expansion of capillaries.

     CREST syndrome patients mainly as calcium deposition, Raynaud's phenomenon, esophageal dysfunction (toe) technology and telangiectasia.